Hypothyroidism and sickle cell may affect Kidney

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Although hypothyroidism this is a site in which the thyroid gland does not produce enough thyroid hormone -which is common in haemodialysis (Kidney) patients, it's unclear how it affects their health and quality of life. Increase of thyrotrophic levels may effect multiple areas of health-related quality of life, including energy/fatigue, physical function, and pain.

"Given the high prevalence of thyroid dysfunction and low levels of quality of life in dialysis patients, many research is needed to determine the underlying mechanisms of these associations, and whether replacement of thyroid hormone can improve the health-related quality of life of this population.” In addition, as the first study in dialysis patients to document an association between higher thyrotropin levels and low levels of physical function, a strong predictor of death, future studies are needed to determine whether correction of thyroid status with exogenous thyroid hormone can improve physical function in this population."

Sickle cell disease, a blood disorder, can impact the function of the kidneys, and the earliest sign of kidney damage in affected patients is albuminuria, or the presence of albumin in the urine

Hydroxyurea (HU), which makes red blood cells more flexible, is one of the cornerstones of sickle cell disease treatment, but its effects on kidney function are unclear. Adults with sickle cell disease who were starting HU therapy. After 6 months of treatment, patients' kidney function, as measured by the urinary albumin/creatine ratio, improved significantly.

"The findings offer further evidence, albeit not yet definitive, of a potential renal benefit of HU, and should strengthen arguments favoring its use in sickle cell disease for other indications and encouraging patient adherence to this drug," "Our preliminary results require additional larger, prospective, randomized, controlled trials to clearly demonstrate the positive effect of HU to reduce albuminuria levels and delay chronic kidney disease progression,"


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